Apical movement during interkinetic nuclear migration is a two-step process
نویسندگان
چکیده
منابع مشابه
Apical movement during interkinetic nuclear migration is a two-step process.
Neural progenitor cells in the pseudostratified neuroepithelium in vertebrates undergo interkinetic nuclear migration, which results in mitotic cells localized to the apical surface. Interphase nuclei are distributed throughout the rest of the epithelium. How mitosis is coordinated with nuclear movement is unknown, and the mechanism by which the nucleus migrates apically is controversial. Using...
متن کاملRegulation of Neurogenesis by Interkinetic Nuclear Migration through an Apical-Basal Notch Gradient
The different cell types in the central nervous system develop from a common pool of progenitor cells. The nuclei of progenitors move between the apical and basal surfaces of the neuroepithelium in phase with their cell cycle, a process termed interkinetic nuclear migration (INM). In the retina of zebrafish mikre oko (mok) mutants, in which the motor protein Dynactin-1 is disrupted, interkineti...
متن کاملInterkinetic Nuclear Migration Is a Broadly Conserved Feature of Cell Division in Pseudostratified Epithelia
Animal development requires tight integration between the processes of proliferative growth and epithelial morphogenesis, both of which play out at the level of individual cells. In this respect, not only must polarized epithelial cells assume complex morphologies, these distinct forms must be radically and repeatedly transformed to permit mitosis. A dramatic illustration of this integration be...
متن کاملInterkinetic nuclear migration: cell cycle on the move.
Interkinetic nuclear migration (INM) is a common feature of developing neuroepithelia, consisting of the periodic movement of the cell nucleus in phase with cell-cycle progression. In this issue of The EMBO Journal, Kosodo et al provide a first molecular mechanism to couple nuclear migration and cell cycle: the microtubule-associated protein Tpx2 redistributes from the nucleus to the apical pro...
متن کاملGap junctions modulate interkinetic nuclear movement in retinal progenitor cells.
During early retinal development, progenitor cells must divide repeatedly to expand the progenitor pool. During G(1) and G(2) of the cell cycle, progenitor cell nuclei migrate back-and-forth across the proliferative zone in a process termed interkinetic nuclear movement. Because division can only occur at the ventricular surface, factors that affect the speed of nuclear movement could modulate ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 2012
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2012.06.031